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Wound Management and Healing with Clireon™

Clireon wound and skin care solution's active ingredient Hypochlorous Acid (HOCl), protects and heals while killing different types of microorganisms and bacteria that could cause infection and compromise healing.  
 
HOCl demonstrated improved wound-healing outcomes in clinical studies and using HOCl also helps to increase the duration of keratinocyte cell line migration within the wound site, a vital component in the cells’ abilities to aid in the healing process.[1]

What leads to a chronic or
non-healing wound?


Chronic wounds are defined as wounds that fail to proceed through the normal phases of wound healing in an orderly and timely manner. Often, chronic wounds stall in the inflammation phase of healing.[2] 
 
Chronic wounds are especially susceptible to biofilms. These organic barriers are actually composed of millions of microscopic organisms, which form over the surface of most wound types. With these biofilms in place, most wounds cannot heal properly, and it’s often these simple obstructions that result in any number of accompanying side effects, including infection and increased blood toxicity.[1]

Wounds typically presenting with a high level of bioburden

Current studies indicate that HOCl, the active ingredient in Clireon, may assist in the management of hard-to-heal chronic wounds by decreasing the bacterial numbers and by penetrating and disrupting the biofilms.[6]


  • Lacerations
  • Bite wounds
  • Shearing wounds
  • Abrasions
  • Infected wounds
  • Abscesses

Wound Assessment and Management

We recommend that you assess the wound and verify there isn’t a more serious issue needing medical attention from a veterinarian. Then stabilize the animal and perform first aid to the injured area as soon as safely possible. Below are First-aid recommendations from the Merck Veterinary Manual.

First Aid: Wound Irrigation/Cleansing


Irrigation of the wound washes away both visible and microscopic debris. This reduces the bacterial load in the tissue, which helps decrease wound complications.
The irrigation also allows for better examination of any underlying tissues.
The most important factor in wound irrigation is the use of large volumes to
facilitate removal of debris.[4]

Clireon™ benefits the wound because:

  • Broad-spectrum antimicrobial activity
  • Non-irritating, non-sensitizing, non-toxic
  • Can be used to loosen encrusted dressings in addition to irrigating loose debris and bacteria from the wound bed
  • Has rapid antimicrobial activity at concentrations safe for animal cells

First Aid: Wound Debridement[4]


After wound preparation and hair removal, debridement can be performed. Debridement may involve removal of large segments of tissue (nonselective) or may be performed in a more selective manner, enabling preservation of specific tissues. Skin and local tissue viability should be assessed before any attempted debridement. Skin that is blue-black, leathery, thin, or white is usually not viable.

Clireon™ can be used to aid in the debridement process:

  • Generously soak gauze and apply it directly to the wound for 3-5 minutes. This helps to clean and loosen necrotic tissue, remove foreign elements, and cellular debris.
  • Use the gauze to gently scrub the wound; use additional debridement tools as needed.

After initial inspection, irrigation, and debridement, a decision must be made whether to close the wound or to manage it as an open wound. If the wound is left open, it should be managed for optimal healing.

First Aid: Open Wound Management


When a wound cannot or should not be closed, open wound management may be appropriate. Such wounds include those in which there has been a loss of skin that makes closure impossible or those that are too grossly infected to close.
Open wound management is based on repeated bandaging and debridement as
needed until the wound heals.[4] 
 
Traditional therapy calls for wet-to-dry dressings initially. The initial wide meshed gauze dressings help with mechanical debridement at every bandage change. Until a granulation bed forms, the bandage should be changed at least once daily. In the early stages of healing, the bandage may need to be changed as often as twice daily. After granulation tissue develops, the bandage should be changed to a dry, nonstick dressing so the granulation bed is not disrupted.[4] 
 
With the newer concept of moist wound healing, bandaging is combined with dead tissue debridement to promote wound healing. The use of moist wound dressings keeps white cells healthier, allowing them to aid in the debridement process.[4]

Hypochlorous Acid, the active ingredient in Clireon, aids in open wound management by helping to keep the wound moist, by helping to remove dressing that may have become adhered during the healing process and by helping keep microbes and remnants of previous dressings from the wound surface. You can use Clireon to saturate wound dressing that may have become adhered to aid in the removal of said dressing, or to saturate wound dressing during heavy exudate production (fluid that has seeped out of the wound especially during times of inflammation) to keep wound healthy and clean.

References:

[1] https://www.woundsresearch.com/article/hypochlorous-acid-ideal-wound-care-agent-powerful-microbicidal-antibiofilm-and-wound-healing

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528992/pdf/wound.2015.0635.pdf

[3] Halim, A. S., Khoo, T. L., & Saad, A. Z. (2012). Wound bed preparation from a clinical perspective. Indian Journal of Plastic Surgery, 45(02), 193-202. doi:10.4103/0970-0358.101277

[4] Winkler, K. (n.d.). Initial Wound Management in Animals - Emergency Medicine and Critical Care. Retrieved from https://www.merckvetmanual.com/emergency-medicine-and-critical-care/wound-management/initial-wound-management-in-animals

[5] Wolcott, R. D., & Fletcher, J. (2014). Technology update: Role of wound cleansing in the management of wounds. Wounds International, 1(1), 33-38. 


[6] Treating Chronic Wounds With Hypochlorous Acid Disrupts Biofilm, Martin C. Robson, MD. https://www.o-wm.com/article/treating-chronic-wounds-hypochlorous-acid-disrupts-biofilm